Why Oregon will win: The Ducks haven't lost consecutive games during a season since 2007, so despite how shaky the offensive line has looked there's not much precedent to expect another loss. Brett Hundley versus Marcus Mariota is intriguing, but look for Mariota to keep his Heisman campaign alive. And playing on the road apparently isn't a tough thing to overcome anymore either -- in Pac-12 games the road team is 11-3 so far this season. -- Kyle Bonagura
Why UCLA will win: Both offensive lines have dealt with injuries -- and thus both quarterbacks have taken the brunt of that issue. But I like UCLA's defensive line against Oregon's offensive line better than Oregon's D-line against UCLA's O-line, especially if Arik Armstead is limited. This is a coin-flip game, but with both teams coming off of emotional losses, I like the team that doesn't have to rebound on the road. -- Kevin Gemmell
Why Washington will win: Cal's only conference game against a team with a winning record this season came against Arizona, and that foray into the desert didn't end well for the Bears because they couldn't put together four quarters of consistent defense (the Wildcats scored 36 points in the final frame). Though Jared Goff (22 touchdowns, three interceptions) has been spectacular and there's every reason to believe he'll be good again Saturday, an athletic Husky front seven will pressure him, and this will likely be a game in which Cal will need at least some help from the defense to win. Washington's Cyler Miles struggled mightily his last time out against Stanford's vaunted defense, but the Bears haven't demonstrated the same ability to slow an opponent down (they're surrendering more than 40 points per game). -- David Lombardi
Why Cal will win: I'm a big fan of Washington's defense. But I'm not sure the offense can go blow-for-blow with the Bears right now. Cal is running the ball effectively enough to keep teams off balance and they are winning in the “explosive play” department. This is by far the toughest front-seven Cal has seen this season. And Washington will get its stops and probably a few sacks. But they are going to need at least 35-42 points on the road to win. That's a tough sell. -- Kevin Gemmell
Why USC will win: The reason I picked USC is because Arizona is undefeated and that's not allowed in the Pac-12 this season. Yes, I love the way the Wildcats have played thus far: opportunistic and mentally tough. That's two things you can't say about USC. But there you have it. What seems like it should happen, won't. The Trojans are going to win this game because the college football gods will not allow any sustained happiness within a Pac-12 fan base this season. -- Ted Miller
Why Arizona will win: Bowl eligibility and a perfect 6-0 start is on the line at home for Arizona. You can guarantee Arizona Stadium will be bumping. I'm expecting a big Wildcats offensive output because, let's be serious, USC has some major defensive deficiencies. They've proven you can throw against them after giving up 510 passing yards to Mike Bercovici. They've proven you can run against them, after giving up 452 rushing yards to Boston College. And guess what, Arizona can both run and throw the ball. If it's the struggling run defense that shows up against the Wildcats, then you can expect Anu Solomon, Nick Wilson and Terris Jones-Grigsby to show out. If it's the struggling pass defense that shows up, you can expect Solomon to connect with Cayleb Jones, Austin Hill and Nate Phillips. Arizona's offense is going to be stellar and its defense, a week after holding Oregon to just 144 rushing yards, is going to do enough to get the win. -- Chantel Jennings
Unanimous decision
Why Stanford will win: Washington State hasn't seen anything like Stanford's defense this year and while the same could also be said about Stanford facing WSU's offense, recent history says this is the Cardinal's game to lose. The real story will be what happens when Stanford's offense is on the field.