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Rapid Reaction: Cardinals 25, Lions 21

GLENDALE, Ariz. -- A few thoughts on the Detroit Lions' 25-21 loss to the Arizona Cardinals.

What it means: This is a rough loss for Detroit. The Lions didn’t play particularly well in any facet -- more on that below -- and still led the game late in the fourth quarter. But penalties -- eight of them for 101 yards -- proved critical. Bill Bentley was called for pass interference to set up Arizona’s game-winning touchdown, and if he had turned around, it would have been fourth down instead of Arizona’s ball on the 1-yard line. Two penalties in the third quarter extended a drive that led to a Cardinals field goal. Just tough mistakes.

Stock watch: Stock up: Detroit’s front seven. DeAndre Levy had an interception return for a touchdown and the Lions were able to play well on third downs and in the red zone. They could challenge to be among the top groups in the NFL by the end of the season. Also up: Calvin Johnson. The best receiver in the NFL had two touchdowns in the first half and set two franchise records. Stock down: Rookie cornerback Darius Slay, who won the starting job out of training camp, was replaced for the second straight week by Rashean Mathis. Keep an eye on this during this week.

Special teams a mess: Just a horrific day on special teams for Detroit. David Akers, who is usually reliable, missed a field goal, had another one blocked and another field goal attempt, which he missed, was nullified by a running into the kicker penalty. Returner Micheal Spurlock struggled returning kicks -- almost causing a safety on a kick return -- and punts, losing yardage on one return after essentially running the width of the field. This is the second straight week there have been some special teams issues for Detroit. Last week, punter Sam Martin muffed a field goal hold and struggled with his kicks.

Offense not the same without Reggie Bush: Detroit’s offense stalled without Bush for the majority of the second half. It gained 90 second-half yards, most of them without Bush.

What’s next: Detroit has its second road game in a row next week, heading to Washington to face Robert Griffin III and the 0-2 Redskins.